Exuberant Granulation


The production of exuberant granulation (Proud-flesh) tissue in wounds healing by second intention is a commonly encountered complication in horses and can significantly delay wound healing.


This is especially the case in wounds located in the distal limb. The horse activates connective tissue structures to a greater extent and earlier than other species. Dermal fibrosis and collagen deposition is excessive, elevating the wound above the skin surface. Histologically, granulation tissue (Proud-flesh) is composed of proliferating fibroblasts and endothelial cells in a connective tissue matrix.


Factors which contribute to the development of exuberant granulation tissue (Proud-flesh) include a relatively poor blood supply to the distal limb, local tissue hypoxia, infection, movement and chronic irritation attributable to topical irritants.


Various studies have shown that certain topically applied products may be of benefit, though none of these products have been proven to consistently eliminate exuberant granulation tissue (Proud-flesh) in the distal limb of horses until now.

Proud Flesh

Clinical Trials


During these trials many of the wounds were left un-bandaged and did not develop Proud flesh.


Despite environmental contamination, the application of Proud-Aid decreased wound surface exposure to contamination and potentially allowed healing to progress with little gross contamination of the actual wound surface.


The ability of the Proud-Aid to remain in place following application is extremely advantageous in horses with wounds left to heal by second intention and without covering.

Before & after
Mikey, shoulder injury

Before & after
Penny, injury above the knee

Before & after
Waddona, back leg injury